How much grapefruit juice is in fresca

Here's one that only just occurred to us as we were meditating on the loveliness of the recently-trending grapefruit-soda-infused Paloma cocktail : have you ever thought about the fact that Fresca was grapefruit soda way before grapefruit soda became a thing via Brisan Group? You already know Fresca has lots of flavor but zero sugar, carbs, and gluten. You already must appreciate the fact that it's a cloudy soda, as opposed to a clear soda, which kind of makes it look like a snowstorm in a glass true fact, that, as you shall soon find out.

And you probably already appreciate that Fresca won't stain your clothes if you dribble as you drink not that you do, but still.

So, really, what more do you need to know? Lots actually! Please join us for the deepest dive anyone has ever taken into everything Fresca. For the fact that Fresca even exists today, Fresca fans have the original on-trend sugar-free slash diet slash low-sugar slash zero-sugar soda to thank: " Tab " stylized as "TaB" for purposes of its logo, may it rest in power, via Snopes. Fresca was the second artificially sweetened soda launched by The Coca-Cola Company.

The first was TaB, which made its debut in with an eye toward attracting the "beautiful" people via Wall Street Journal — or at least the calorie-conscious. Although not everyone loved Tab's literally-saccharin flavor, it was generally so well-received that the idea of following its success up with a sugar-free soda that tasted nothing like cola was an obvious next step. So in , Fresca rolled out to test markets.

When Fresca was first introduced in test markets, Coca-Cola decided to take a novel approach to winning over new consumers. In fact, Coca-Cola decided to take Fresca in a completely different direction — by marketing the citrus-flavored beverage not as an alternative to soda at all, except insofar as sparkling water is considered a soda. In other words, Fresca was positioned as an alternative to seltzer, despite that it has an audacious, rather than a subtle, flavor, and is artificially sweetened.

In addition, Coca-Cola made the very wise decision to cover as many bases as possible with their marketing of Fresca. When Fresca first came out, it was marketed as both a beverage that could stand on its own and as a mixer for alcoholic beverages. And it worked. Boy, did it work because after more than 54 years, not even counting the years during which Fresca was in test markets, Fresca is still happily ensconced in Coca-Cola's permanent lineup well, as permanent as that can be.

And Fresca manages to do so without a record of sales that come even close to classic Coke's, according to Deseret News , which pointed out that for , just for comparison's sake, Fresca's sales were at Of course, it doesn't hurt that the love for Fresca stands as a unifying characteristic of Generation X via YouGov.

When Fresca was first introduced by the Coca-Cola company back in , the marketing team was searching for a way help consumers to distinguish, and perceive the added value represented by, Fresca — versus its recently released zero-calorie, cola-flavored older-sibling, Tab. What they ended up coming up with was the idea that Fresca offered a "blizzard" of taste.

Now, that might have made a bit more sense if Fresca hadn't been launched in the dead of winter. Or looking at it from a different perspective, perhaps it made perfect sense because if you take a look at a glass of Fresca, you can see that it does kind of, at least abstractly, resemble a well-contained snowstorm.

And since Fresca was launching in February, perhaps the marketing team thought that associating Fresca with a winter weather condition was almost like sending a subliminal message via Business Insider. As it turned out, the marketing team behind Fresca's launch deserved big-time props because Fresca's big launch party in New York City coincided with one of winter 's biggest snowstorms.

When "Fresca was ready for the big time," Coca-Cola writes on its webpage devoted to Fresca's origin story, only one venue seemed to represent the brand's new beverage properly, and that was New York City. More specifically, that meant the then-four-years-old-but-already-renowned restaurant, the Four Seasons, which opened in in the "architecturally acclaimed Seagram's building" at the super high-end intersection of Park Avenue and 52nd Street in midtown Manhattan.

Architecture buffs may know the restaurant's interior space because of its own architectural significance. To entertain guests, Coca-Cola hired 's version of an alt-rock star, Mitch Miller, who hated pop music according to "Jazz Singing" by Will Friedwald Scribners , via Festive Fanzine but was nevertheless commissioned to write and record an apropos theme song for the fete.

The "Blizzard Theme" is still available on vinyl today via Amazon. And yes, there was a blizzard that day, but that worked right into Coca-Cola's plans! Diet soda is as popular as it is controversial, according to Healthline. So grapefruit juice may affect people differently even when they take the same drug.

Although scientists have known for several decades that grapefruit juice can cause too much of certain drugs in the body, more recent studies have found that the juice has the opposite effect on a few other drugs. Fexofenadine brand name Allegra is available as both prescription and OTC to relieve symptoms of seasonal allergies. Why this opposite effect? Instead of changing metabolism, grapefruit juice can affect proteins in the body known as drug transporters, some of which help move a drug into our cells for absorption.

As a result, less of the drug enters the blood and the drug may not work as well, Huang says. Grapefruit juice can cause problems with these enzymes and transporters, causing too much or too little drug in the body. Some drugs, like certain statins used to lower cholesterol, are broken down by enzymes.

Learn More. The interaction between grapefruit-containing beverages and immunosuppressants is not well defined in the literature. This study was conducted to investigate possible sources of grapefruit juice or grapefruit extract in common US-manufactured beverages.

Twenty-three beverages were identified that contained grapefruit. In addition to the confirmed grapefruit-containing products, 17 products were identified as possibly containing grapefruit juice or grapefruit extract. A greater emphasis should be placed upon properly educating patients regarding hidden sources of grapefruit in popular US beverages and the potential for food-drug interactions.

Grapefruit is an excellent source of vitamins and phytochemicals. Yet, grapefruit has been linked to many significant drug interactions. The well-documented interaction between grapefruit and grapefruit-containing products and certain medications has been attributed to several different potential mechanisms of interaction. The interference of intestinal cytochrome P CYP enzymes by grapefruit furanocoumarin derivatives is currently accepted as the primary mechanism of interaction.

The CYP system is a diverse family of over 60 enzymes that function to catalyze the oxidation of organic substances.

Active chemical compounds in grapefruit, known as the furanocoumarins , are primarily responsible for the CYP 3A4 interaction. This inhibition of intestinal clearance by CYP3A4 requires de novo restoration of the isoenzyme prior to returning to normal metabolic function. Of additional interest is the interference with P-glycoprotein and organic anion transporting peptides by grapefruit bioactive compounds. In contrast to CYP enzyme interference, these mechanisms of interaction are competitive and relatively short-lived.

Many immunosuppressants, including cyclosporine, tacrolimus, sirolimus, and everolimus, are known to interact with grapefruit, and therefore most transplant recipients are at risk for drug-food interactions 4 Table 1. In patients receiving immunosuppressants after organ transplant, rejection, medication toxicity, and infections are all possible negative consequences of medication interaction.

Subtherapeutic levels of immunosuppressants may result in rejection, and supratherapeutic levels may result in toxicity or infection. Immunosuppressant medications that have the potential for significant interactions with grapefruit and grapefruit-containing products 4 - The most commonly documented immunosuppressant interactions are with grapefruit and cyclosporine 5 - 13 followed by tacrolimus and grapefruit.

The patient routinely drank an unreported amount of Sun Drop with breakfast; Sun Drop contains grapefruit juice or bergamottin, a natural furanocoumarin. Conflicting evidence was reported in a randomized, 4-way crossover study with a 1-week washout period that studied changes in cyclosporine concentrations due to citrus sodas.

Each drink was consumed 2 times on the day before and 3 times on the study day. This study found that there was no significant alteration in cyclosporin concentrations. The current literature fails to provide a comprehensive list of beverages containing grapefruit or grapefruit juice and, as such, does not allow a pharmacist to educate patients on the possible hidden sources of food-drug interactions.

The purpose of this study was to compile a comprehensive list of popular beverages manufactured in the United States that contain or possibly contain grapefruit constituents. This list will provide an additional resource for patient counseling regarding potential food-drug interactions, specifically interactions with immunosuppressant agents.

Popular US manufacturers of beverages and their products were identified. Telephone calls were made to each manufacture to identify beverages that contained grapefruit or grapefruit extract. Products were defined as containing grapefruit or possibly containing grapefruit. Products that contained grapefruit were verifiable or confirmed as containing grapefruit either via a call to the manufacture or acknowledgment in the product labeling. Products that possibly contained grapefruit were defined as those that had a listing of citrus flavors or ingredients that were unable to be confirmed or discounted as grapefruit or grapefruit extract.

The beverage product review resulted in several products that contained verifiable amounts of grapefruit or grapefruit extract Table 2. In addition to the confirmed grapefruit-containing products, 17 products were identified as possibly containing grapefruit juice or grapefruit extract Table 3. This study identified beverages that may contain grapefruit via telephone queries and product review.

We conducted a thorough product search of popular beverages produced by US manufacturers and compiled a list of beverages that did contain grapefruit or grapefruit extract and a secondary list of products that potentially contain grapefruit. One limitation to our literature review is conflicting evidence supporting a clinically significant grapefruit juice-like interaction between immunosuppressants and citrus sodas that contain grapefruit as a constituent.

The published case study of tacrolimus and SunDrop 17 appears to indicate that the potential exists for significant interaction, although a controlled pharmacokinetic study 18 failed to support this hypothesis. These conflicting data may be explained by patient variability.

There is high individual variability of CYP3A4 content in the general population, and therefore the effect of inhibition may be unpredictable.